An excerpt from the 1815 book The History of the Small Pox by James Carrick Moore.

In this excerpt, Moore describes the calamities and deaths caused by smallpox in the fifteenth and sixteenth centuries as a result of European colonization of the Americas. Smallpox was one of the most devastating consequences of the Columbian Exchange. Diseases brought to the Americas by Europeans after the Columbian Exchange caused a population decline among Native Americans that was the largest in human history.