Orthoclone OKT3 Muromonab-CD3
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- Created Date
- ca 1986
Orthoclone OKT3 prevents rejection of new tissues in patients who have received kidney grafts. It was the first drug created through monoclonal antibody technology to be approved for human use.
Monoclonal antibody technology uses specially made cells as tiny factories to pump out pure sources of a single antibody. Prior to its development, it was very difficult to isolate large amounts of a single antibody for therapeutic use.
Monoclonal antibody cells are created by fusing two cells of different origins. One cell, from a mouse's spleen, produces the antibody. The other cell, from a tumor, has the ability to replicate continuously. By fusing the two cells, a new cell is created which has the best characteristics of both-it produces the antibody and also grows quickly. These new cells produce large amounts of pure antibodies which are harvested for use in drugs like Orthoclone OKT3.
The object is a clear glass 5 mL ampule with a blue ring around the neck and a clear label with blue printing. It is housed in a formfitting plastic case with snap top and snap sides.
Currently not on view
- Ortho Pharmaceutical Corporation
- Smithsonian Institution
- Contributing Institution
- National Museum of American History
- Health & Medicine
Biotechnology and Genetics
The Antibody Initiative
Ortho Pharmaceutical Corporation
Science & Mathematics
- Gift of Ortho Pharmaceutical Corporation
- Chicago citation style
- Ortho Pharmaceutical Corporation. Orthoclone OKT3 Muromonab-CD3. ca 1986. Retrieved from the Digital Public Library of America, http://collections.si.edu/search/results.htm?q=record_ID%3Anmah_1000965&repo=DPLA. (Accessed November 21, 2018.)
- APA citation style
- Ortho Pharmaceutical Corporation, (ca 1986) Orthoclone OKT3 Muromonab-CD3. Retrieved from the Digital Public Library of America, http://collections.si.edu/search/results.htm?q=record_ID%3Anmah_1000965&repo=DPLA
- MLA citation style
- Ortho Pharmaceutical Corporation. Retrieved from the Digital Public Library of America <http://collections.si.edu/search/results.htm?q=record_ID%3Anmah_1000965&repo=DPLA>.